Federated Learning (FL) allows for secure analysis of distributed data without data sharing.
We and others have successfully applied FL to neuroimaging tasks, such as Alzheimer's disease classification from structural magnetic resonance imaging (MRI).
FL trains a deep learning model locally at each site, encrypts the local model parameters and sends them to a federation controller that aggregates the local models under homomorphic encryption, the resulting community model is sent back to the sites for further training, and the process repeats for a number of rounds.
FL often achieves learning performance (e.g., accuracy) close to centralized training, but no data leaves the sites and model parameters are protected through encryption and other measures.
In this paper, we show that federations composed of sites with heterogeneous amounts of data (1 large site plus small sites) perform better than homogeneous (same data per site) federations, particularly in low data regimes, while reaching performance close to centralized training.
Having a big site often results in faster convergence and higher final accuracy.
Heterogeneous federations better exploit sites with small amounts of data, a common situation in large consortia such as ENIGMA.